Work

Improved endoscope for imaging and cell collection in the fallopian tubes

Year: 2026

Type: article

Abstract: SignificanceEarly detection of ovarian cancer requires the observation of subtle changes within the fallopian tubes, where serous tubal intraepithelial carcinoma lesions, the putative precursor of high-grade ovarian serous carcinoma, may be present and detectable.AimThe cell-acquiring fallopian endoscope was designed to detect and interrogate potentially pathological sites in the fallopian tubes via alterations in fluorescence signal and the collection of epithelial cells.ApproachWe performed a comprehensive redesign of a first-generation endoscope prototype and demonstrated its performance in whole, human ex vivo fallopian tubes. Through the iterative improvements to the design, the endoscope features improved imaging, cell collection, and general ease of use. Specifically, improvements included a larger core count fiber imaging bundle, a redesigned close-focus lens, more flexible materials, an altered cell collection method, and a lighter-weight handle.ResultsWith benign fallopian tube samples from three patients, we demonstrate cell collection on the order of 104 cells per collection and imaging capabilities that result in average image intensity ratios.ConclusionsThis second-generation endoscope is suitable for the study of intact fallopian tubes.

Source: Biophotonics discovery.

DOI: 10.1117/1.bios.3.2.025001