Work

Intrathecal synthesis of Epstein-Barr virus antibodies 15 years before onset of multiple sclerosis

Year: 2026

Type: article

Abstract: A 48-year-old woman was diagnosed with multiple sclerosis (MS) in 2019. She participated with blood and cerebrospinal fluid samples as a spinal anaesthesia surgery patient for a case-control study on viruses and MS in 2003. The study had already demonstrated intrathecal antibody synthesis (ITS) to Epstein-Barr virus (EBV) but not against measles, rubella and varicella-zoster (MRZ) reaction viruses in this individual at the time of recruitment. A 2025 study review established that she was the only patient in her control subgroup who also developed MS. This case shows that a specific EBV-ITS may be an early indicator of a 'biologically isolated syndrome' in MS.

Source: Multiple Sclerosis Journal

DOI: 10.1177/13524585261427398

Authors: Manuel Miguel Guerrero-Fernández, Carmen Serrano-Álvarez, Jesús Foronda-Bengoa, Francisco Javier Barrero-Hernández, Antonio Sorlózano-Puerto

Institutions: Universidad de Granada, Complejo Hospitalario de Jaén, Instituto de Investigación Biosanitaria de Granada

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7138305356