Magnetic Field-Responsive Smart bioMOF Composites Based on Bi(III)-Ellagate SU-101
Year: 2026
Type: article
Abstract: Bioderived metal-organic frameworks (bioMOFs) have attracted interest as functional materials for medical-related applications due to their biocompatibility and structural tunability. However, the integration of external stimulus responsiveness into bioMOF architectures while preserving the framework integrity remains a significant challenge. Herein, we report the synthesis and comprehensive characterization of magneto-responsive nanocomposites based on the microporous Bi(III)-ellagate bioMOF SU-101 incorporating ultrasmall magnetic nanoparticles. We demonstrate the successful integration of magnetic nanoparticles and the loading of fluorescent cargo within the MOF matrix without compromising its structural integrity. The resulting magnetic nanocomposites exhibit a well-defined magnetic response under high-frequency alternating (AMF) and low-frequency rotating (RMF) magnetic fields that enable remote modulation of thermal and mechanical effects, leading to significant cargo release and a marked reduction in cancer cell viability. Moreover, magnetic resonance imaging (MRI) relaxivity measurements confirm the potential of these nanocomposites as magnetic resonance contrast agents. Overall, these results highlight the strong potential of magnetically responsive bioMOF SU-101-based nanocomposites as multifunctional platforms for biomedical applications.
Authors: Darina Francesca Picchi, Catalina Biglione, Julie Charlotte Pauline Mellerin, Doha Zorkot, Pascal Clerc, Manon Boulet, Safiyye Kavak, Pablo Cristóbal-Cueto, Ana Maria Panaite, Erik Svensson Grape, A. Ken Inge, Sara Bals, Julian Carrey, Teresa Pellegrino, Véronique Gigoux, Patricia Horcajada
Institutions: Madrid Institute for Advanced Studies, Universidad Rey Juan Carlos, IMDEA Energy Institute, Centre National de la Recherche Scientifique, Université Toulouse III - Paul Sabatier, Inserm, Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, Institut National des Sciences Appliquées de Toulouse, Laboratoire de Physique et Chimie des Nano-Objets, University of Antwerp, Italian Institute of Technology, Stockholm University
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Awards: Three dimensional investigation of the atomic structure of MOFs by in situ transmission electron microscopy to understand diffusion and degradation mechanisms, polyMOFs as promising drug delivery systems for antimicrobial therapy, Three dimensional investigation of the atomic structure of MOFs by in situ transmission electron microscopy to understand diffusion and degradation mechanisms, G5245487910
OpenAlex ID: W7138309888