Work

290P Immunotherapy-adjusted locoregional complexity score to anticipate surgical difficulty after neoadjuvant immune checkpoint inhibition

Year: 2026

Type: article

Abstract: Neoadjuvant immune checkpoint inhibitors are increasingly used for locally advanced thoracic cancers, but therapy-related inflammation and fibrosis can obscure surgical planes, especially around major mediastinal and hilar vessels. To better anticipate operative complexity in this evolving setting, we developed an Immunotherapy-Adjusted Locoregional Complexity (IALC) score that incorporates anatomic proximity to critical vascular structures and the extent of immune-mediated tissue remodeling.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2026.106599

Authors: M. Klimatsidas, A. Karatzopoulos, T.G. Kelpis

Institution: St. Luke's Hospital

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,910