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Additional file 1: Figure S1. of Local compartment changes and regulatory landscape alterations in histone H1-depleted cells

Year: 2015

Type: article

Abstract: DNA methylation changes per chromosome in histone H1-depleted ES cells. Figure S2. Hypomethylation in TKO cells occurs preferentially in gene-dense TADs regardless of GC content. Figure S3. ChIP-seq of four different histone marks in wild-type and TKO mouse ES cells. Figure S4. Large-scale changes in H3K4me1 and H3K4me3 sites upon depletion of histone H1. Figure S5. Analysis of DNA binding motifs at de novo formed DHSs in TKO cells. Figure S6. Over 10 % of de novo formed DHSs also show loss in CpG methylation in H1 TKO cells. Figure S7. Active chromatin marks accumulate in the most gene-dense TADs. Figure S8. Higher-order genome topology is very similar between wild-type and histone H1 TKO cells. Figure S9. Changes in compartment organization are not related to gene content, TAD size or differential expression. (PDF 4637 kb)

Source: Figshare

DOI: 10.6084/m9.figshare.4329077

Authors: Geeven, Geert, Zhu, Yun, Kim, Byung, Bartholdy, Boris, Yang, Seung-Min, Macfarlan, Todd, Gifford, Wesley, Pfaff, Samuel, Verstegen, Marjon, Pinto, Hugo, Vermunt, Marit, Creyghton, Menno, Wijchers, Patrick, Stamatoyannopoulos, John, Skoultchi, Arthur, de Laat, Wouter

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7138369608

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