Additional file 11: of CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types
Year: 2016
Type: article
Abstract: Performance evaluation of CellMapper and other computational methods to recover genes expressed in four major brain cell classes: neurons, astrocytes, oligodendrocytes, and microglia. Unlike the neural cell types examined in Fig. 2 and Additional file 16, these four cell classes are fairly common in the brain and have been successfully analyzed by previous computational algorithms. Each method was evaluated based on the recovery of an experimentally defined [6] set of cell type-enriched genes in mouse, as quantified by the area under the precision recall curve (AUPR). All methods show some resolution to resolve genes expressed in these cell types, but the best performance was consistently from CellMapper and in silico nano-dissection. (PDF 24 kb)
Source: Figshare
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7138488198