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Site-Specific Adaptive Milk-Derived Nanovesicles Redefine the Landscape of Oral Insulin Delivery

Year: 2026

Type: article

Abstract: Overcoming gastrointestinal degradation, epithelial impermeability, and hepatic clearance has been the long-sought goal in oral insulin delivery. Xia et al.’s pioneering work in Science Advances achieves a paradigm shift using site-specific adaptive milk-derived nanovesicles (MiNVs). Engineered from bovine milk exosomes and biothiol-responsive liposomes, MiNVs exploit IgG-FcRn transcytosis for efficient intestinal uptake and glutathione-activated release in the liver. This dual-mechanism enables sustained glycemic control and high oral bioavailability in rodent and porcine diabetic models. More than an incremental advance, this represents a transformative leap toward physiological, injection-free insulin therapy.

Source: MedMat.

DOI: 10.1097/mm9.0000000000000043

Authors: Xiaojing Wang, Jinjin Wang, Qiao Wu, Juan Liu, Xinhua Xiao

Institutions: Beijing Tsinghua Chang Gung Hospital, Tsinghua University, University of Pennsylvania, Capital Medical University, Beijing Tian Tan Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7138947423

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