Year: 2015
Type: article
Abstract: Background: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.
Source: Touro Scholar (Touro College)
Institutions: Helmholtz Munich, Universidade de Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases, Instituto de Investigación Sanitaria de Santiago, Beth Israel Deaconess Medical Center, Charité – Universitätsmedizin Berlin, Instituto de Salud Carlos III, Hospital Infantil Universitario Niño Jesús, Centro de Investigación Biomédica en Red, Universidad Autónoma de Madrid, St. Luke's-Roosevelt Hospital Center, Columbia University
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7139809353