Work

A multifaceted kinase keeps molecular motors in place for faithful cell division

Year: 2026

Type: article

Abstract: During cell division, faithful chromosome segregation is ensured by the mitotic spindle. van Toorn et al. 1 uncovered that Cdk1-mediated phosphorylation of the dynein-activating adaptor NuMA promotes the timely assembly of dynein/dynactin/NuMA complexes, essential for correct mitotic progression and genome integrity.

Source: Cell Reports

DOI: 10.1016/j.celrep.2026.117214

Authors: Paola Ghezzi, Marina Mapelli

Institution: European Institute of Oncology

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,620

OpenAlex ID: W7139987239

FWCI:

Cites: 6

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