Work

Flavonoids as chemopreventive agents: metabolism, apoptosis, and oxidative stress modulation

Year: 2026

Type: article

Abstract: Background: Liposomes are widely used as drug delivery systems because of their reduced systemic toxicity. Over the past few decades, numerous drug-loaded liposomes have been approved for clinical use in the treatment of cancer, viral, and fungal infections. Various liposomal formulations have progressed to later phases of clinical trials. Liposomes are spherical vesicles composed of a single or multiple phospholipid bilayers surrounding an aqueous core. Drug-loaded liposomes can exhibit controlled or targeted drug delivery, low immunogenicity, high biocompatibility, biodegradability, prolonged drug half-life, increased efficiency, reduced systemic toxicity, and enhanced pharmacokinetic properties. Methodology: This review article addresses the characteristics and types of liposomes; novel methods for their preparation, such as the Supercritical Anti-solvent Method and the Dual Asymmetric Centrifugation Method; lipid preferences; future directions for liposomes; marketed liposomal formulations; and associated patents. Results and Discussion: It has the potential to protect the drug against degradation. The aforementioned drug delivery system increases in vivo drug distribution toward target sites. PEGylated liposomes can prolong circulation time. It requires expertise in techniques, such as thin-film hydration and reverse-phase evaporation, for preparation. It has been utilized in nanomedicine. This particular delivery system requires characterizations like size, drug loading, drug release, etc. Conclusion: Liposome-embedded delivery systems advance nanotechnology and biopharmaceutics. The role of modern medicine has continued to expand, particularly in the management of chronic diseases.

Source: Journal of Applied Pharmaceutical Research

DOI: 10.69857/joapr.v14i2.1486

Authors: Faruk Alam, Surabhi Mandal, Bhupendra Shrestha, Barasha Bharadwaj, Bramhajit Chatterjee

Institutions: Assam Down Town University, Brainware University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $100