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Enhanced hypoxia resistance distinguishes human pluripotent stem cell-derived islets from primary islets

Year: 2026

Type: article

Abstract: This study provides the first quantitative evidence that human stem cell-derived islets are more resistant to hypoxia than primary human islets. Stem cell-derived islets maintain viability at substantially lower oxygen levels and exhibit markedly reduced variability in hypoxia tolerance. These findings identify hypoxia resistance as a key functional advantage of stem cell-derived islets, with important implications for transplantation into low-oxygen environments and for scalable islet fabrication strategies.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00043.2026