Expert Consensus on the use of autologous platelet-rich plasma in the context of regenerative medicine: moving forward to good clinical practice.
Year: 2026
Type: article
Abstract: INTRODUCTION: This paper summarizes the conclusions of the Expert Consensus (EC) on the use of platelet-rich plasma (PRP) in regenerative medicine. The initiative aimed to promote appropriate and effective clinical use of PRP based on current scientific evidence and expert experience. The main objectives are: to define a flexible operative range for PRP, allowing for personalized application; to establish principles for standardized clinical practice. METHODS: The methods used to develop this EC involved the scientific literature review, the data quality assessment, the evaluation of practical experiences, the critical summary of reviewed literature, the development of questions for expert panel and the drafting of consensus statements. RESULTS: Recommendations emphasize compliance with legislation, proper device use and operator training. Adequate platelet load is essential for therapeutic efficacy; platelet recovery should be considered as quality standard. PRP has demonstrated effectiveness in managing diabetic and venous ulcers, osteoarthritis, and tendinopathies, although variability in protocols and inconsistent reporting limit the strength of evidence. Emerging applications include vasculitis, mucositis, and urogenital conditions, although further research is needed. CONCLUSIONS: The EC encourages multicentre research, strict publication standards, and international collaboration to strengthen scientific foundations for PRP use in regenerative medicine.
DOI: 10.4415/ann_26_01_05
Authors: Massimo Danese, Vittoria D'Esposito, Rosario Miranda, Vincenza Dolo, Ilaria Giusti, Alessio Borean, Donato Rosa, Bruno Amato, Anna Rughetti, Valentina Del Greco, Laura Mazzucco, Antonio Aversa, Valter Cassutti, Francesco Casabona, Alfonso Maria Irollo, Carlo Setacci, Eugenio Caradonna, Andrea Ascoli Marchetti, Gaetano Caloprisco, Michele Angelo Farina, Pietro Formisano
Institutions: Azienda Ospedaliera San Giovanni Addolorata, National Research Council, University of L'Aquila, Azienda ULSS n. 1 Dolomiti, University of Naples Federico II, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Magna Graecia University, MultiMedica, University of Siena, Centro Diagnostico Italiano, University of Rome Tor Vergata
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7140079570