Get started
Work

Successful Outcome of Rhino-Orbital-Cerebral Mucormycosis With Extensive Intracranial Disease in a Patient With Poorly Controlled Diabetes

Year: 2026
Type: article
Study design: Case Report
Abstract: Rhino-orbital-cerebral mucormycosis is a life-threatening infection typically requiring complete surgical debridement of necrotic tissue for survival. The authors have reported a case of invasive mucormycosis in a 22-year-old female with severe diabetic ketoacidosis and recent COVID-19 infection. The patient developed extensive intracranial disease, including cavernous sinus thrombosis and internal carotid artery occlusion, which precluded complete surgical source control without extensive morbidity. Facing such circumstance, a multidisciplinary team pursued an aggressive, individualized multimodal strategy. This included high-dose liposomal amphotericin B, targeted serial endoscopic debridements of extracranial disease, and adjunctive therapies comprising iron chelation (deferasirox), hyperbaric oxygen, and combination antifungal therapy with caspofungin and posaconazole. Despite the inability to achieve complete surgical clearance, this regimen halted disease progression and resulted in clinical and radiological regression. This case illustrated that a coordinated, multimodal approach utilizing aggressive medical management can achieve favorable outcomes in select patients with otherwise inoperable, extensive intracranial mucormycosis.
DOI: 10.7812/tpp/25.229
Authors: James Dorroh, CW David Chang, Eric Y Du, D Matthew Shoemaker, Tabitha Galloway, Carisa Petris, Sachin Patil, Mohammed Alnijoumi, Hariharan Regunath
Institutions: Stanford Medicine, Stanford University, University of Missouri, University of Kansas Medical Center, CoxHealth, Henry Ford Health, Henry Ford Hospital, University of Maryland Baltimore Washington Medical Center
Language: English
Field: Medicine
Open Access status: hybrid
OpenAlex ID: W7140084861
FWCI:
Cites:
Cited by:
Related to: