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Elevated maternal cholesterol is linked to a coexpression network of neonatal indole metabolism and birth weight

Year: 2026
Type: article
Study design: Observational Study
Abstract: This study identifies a coexpression network module connecting birth weight with cord blood indole metabolites, highlighting an integrated neonatal growth-metabolism signature. Maternal lipid status tracks with this signature, adding molecular resolution to the developmental origins of health and disease (DOHaD) paradigm by implicating growth-linked biochemical perturbations in gut-derived indole metabolites. Given the established relevance of indole metabolites to cardiovascular health, our preliminary results motivate future studies aimed at targeting neonatal metabolism as an early window for cardiovascular health intervention.
DOI: 10.1152/ajpheart.00854.2025
Authors: Lik Hang Wu, Jielin Yang, Leroy Sivappiragasam Pakkiri, Lara J. Monteiro, Reyna Peñailillo, Poh Leong Lim, Mahesh A. Choolani, Matthew W. Kemp, Ling-Jun Li, Claudette Cantin, Ignacio Valenzuela, Andrea Leiva, Chester Lee Drum, Sebastián E. Illanes
Institutions: National University of Singapore, National University Health System, Kitasato University, Universidad de Los Andes, Women and Infants Research Foundation, Agency for Science, Technology and Research, San Sebastián University, Universidad de Los Andes, Chile
Language: English
Field: Medicine
Open Access status: hybrid
Awards: G2710842683, G4592956716, G5437477210, G6871576169, G7472056268, G8022331968, G8052172309, G8168460817
OpenAlex ID: W7140091358
FWCI: 28.4
Cites: 66
Cited by: 3
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