Work

Split‐Mouth Comparison Between Autologous Dentin and Heterologous Bone in Bone Regeneration: Clinical Study on 15 Patients

Year: 2026

Type: article

Abstract: OBJECTIVES: This study aims to compare the efficacy of heterologous bone grafts to autologous dentine-derived grafts (processed with the Tooth Transformer) in promoting bone regeneration in patients with posterior maxillary atrophy. MATERIALS AND METHODS: A prospective, split-mouth study was performed on 15 patients (mean age 52 ± 8 years) with symmetrical post-extraction sites in the jaw. All patients received a heterologous bone graft on one side and an autologous dentine graft on the other. We evaluated new bone formation 4 months after surgery through histomorphometric analysis. Statistical analysis was carried out using paired t-tests and Wilcoxon tests, with a significance level of p < 0.05. RESULT: A histomorphometric evaluation revealed a significantly higher percentage of new bone formation in the sites treated with autologous dentine (mean 37.68%) compared to heterologous bone (mean 24.05%). The mean discrepancy between the groups was 13.63% (p < 0.001). Autologous dentine exhibited superior osteoinductive potential, attributable to the presence of bioactive molecules such as BMPs and Type I collagen, which were absent or denatured in heterologous bone. Both materials provided effective three-dimensional scaffolding, but dentine showed earlier osteoblastic colonization and enhanced biological activity at the grafting site. CONCLUSION: Autologous dentine-derived grafts processed by the Tooth Transformer significantly outperform heterologous bone in terms of new bone formation in maxillary atrophy. The study highlights the potential of dentine as a promising regenerative biomaterial, offering a safe and effective solution tailored to individual patients, thereby reducing the need for additional donor sites or synthetic alternatives.

Source: Clinical and Experimental Dental Research

DOI: 10.1002/cre2.70324

Authors: Francesco Ferragina, Angelo R. Sottile, Selene Luccisano, Maria Giulia Cristofaro

Institutions: Magna Graecia University, Azienda Ospedaliero-Universitaria "Renato Dulbecco", Federico II University Hospital, University of Naples Federico II

Language: English

Topic: Dental Implant Techniques and Outcomes

Subfield: Oral Surgery

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,440