Work

Percutaneous coronary intervention in patients aged ≤40 years: a 10-year single-centre cohort study

Year: 2026

Type: article

Abstract: Background: Coronary artery disease (CAD) in adults aged ≤40 years is increasing, yet long-term outcomes after percutaneous coronary intervention (PCI) in the drug-eluting stent (DES) era remain unclear. We aimed to identify procedural patterns and prognostic factors in this very young cohort. Methods: lesions (≥70% stenosis) between 2014 and 2024. Baseline characteristics, quantitative coronary angiography, and procedural data were collected. The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE). Cox regression identified independent predictors. Results: Patients were 82% men (mean age 36.8 ± 4.9 years) with a median SYNTAX score of 16. Procedural success was 98.4% with 93.9% DES implantation and 85.9% radial access. Over 1,620 patient-years (median 5.2 years), MACCE occurred at 27.8 per 1,000 patient-years (5-year cumulative 14.2%). Cardiac mortality was 3.7 per 1,000 patient-years. Diabetes [adjusted hazard ratios (HR) 1.78, 95% confidence interval (CI) 1.06-2.99], SYNTAX score ≥23 (HR 2.01, 1.19-3.40), and dual antiplatelet therapy <12 months (HR 1.62, 1.00-2.64) independently predicted MACCE. Conclusions: Young adults undergoing PCI exhibit complex anatomy but low cardiac mortality. Diabetes, angiographic complexity, and abbreviated antiplatelet therapy are key drive of adverse events, warranting intensive prevention and optimised antiplatelet strategies.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2026.1748236

Authors: Lining Liang, Chunsong Wang, Huawei Dong

Institution: Liaocheng People's Hospital

Language: English

Topic: Coronary Interventions and Diagnostics

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801