Work

Clinical application of the REVEAL™ fluorescence loupe in oral lesion assessment: a five-case clinical note

Year: 2026

Type: article

Abstract: PURPOSE: To illustrate the clinical use and feasibility of the REVEAL™ fluorescence loupe as an adjunctive tool in the chairside assessment of inflammatory, potentially malignant, and malignant oral lesions. METHODS: Five patients with oral lesions were clinically examined under natural light and with the REVEAL™ loupe. When indicated, biopsy and histopathological analysis were performed RESULTS: Inflammatory lesions exhibited a bright and homogeneous red autofluorescence pattern. Actinic cheilitis demonstrated heterogeneous brownish autofluorescence with whitish areas. Squamous cell carcinomas did not show significant autofluorescence contrast. The presence of biofilm was highlighted by a distinct orange signal. CONCLUSION: The REVEAL™ loupe may support the clinical assessment of oral lesions by illustrating autofluorescence patterns associated with underlying tissue changes. However, its use should be considered complementary to biopsy, not a diagnostic substitute.

Source: Lasers in Medical Science

DOI: 10.1007/s10103-026-04861-0