Work

Snapshot on Cell-to-Cell Communication Nanotubes: From Bacteria to Humans

Year: 2026

Type: article

Abstract: From bacteria to higher vertebrates, cells have developed different systems to communicate with each other and transmit specific signals in a dynamic interplay with neighborhood cells. This review focuses on cell-to-cell communication mediated by nanotubes, membrane protrusions present during evolution from bacteria to higher plants and animals. We describe the basic structure of nanotubes in different organisms and cell types and their functions, which cover transfer of signaling molecules, ions, organelles and pathogens in a cell- and context-dependent manner, thereby promoting cell survival, tissue development, response to stress, pathogens' spreading and drug resistance. We also provide an overview of recent studies that are broadening our understanding of the role of these conduits in the pathogenesis of high-incidence diseases in humans, such as cancer and neurodegeneration.

Source: Biology

DOI: 10.3390/biology15060513

Author: Loredana Moro

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258