Work

Endothelial CD44 cleavage by ADAM17 impairs shear stress mechanotransduction

Year: 2026

Type: article

Abstract: Impaired flow-mediated dilation (FMD) is an indicator of endothelial dysfunction in type 2 diabetes (T2D). However, the exact cellular and molecular mechanisms contributing to impaired mechanotransduction of shear stress in T2D are incompletely understood. This work supports the novel concept that increased endothelial activity of a disintegrin and metalloproteinase 17 (ADAM17) causes cleavage of cell-surface CD44, leading to loss of hyaluronan (HA)-associated shear stress mechanotransduction.

Source: Function

DOI: 10.1152/function.113.2025

Authors: Gavin Power, Min Jeong Cho, Jesus H. Beltran-Ornelas, Marc A. Augenreich, Natnicha Imkaew, Olubodun M. Lateef, Francisco I. Ramirez-Perez, Larissa Ferreira-Santos, Camila Manrique-Acevedo, Luis A. Martinez-Lemus, Jaume Padilla

Institutions: University of Missouri, Universidade de São Paulo, Harry S. Truman Memorial Veterans' Hospital

Language: English

Topic: Proteoglycans and glycosaminoglycans research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: American Heart Association, Fundação de Amparo à Pesquisa do Estado de São Paulo, National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: Restoring vasodilator actions of insulin in patients with type 2 diabetes, Development of Novel Tools to Study Mechanisms of Endothelial Insulin Resistance and Dysfunction in Obesity and Diabetes, The HIF2alpha-neuraminidase axis as a mechanism of endothelial dysfunction, G876207116, ADAM17 mediated cleavage of CD44 impairs mechanotransduction of shear stress, G9000042004, G9000113953

OpenAlex ID: W7140103260

FWCI: 12.25

Cites: 40

Cited by: 4

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