Work

Oxidative stress and the therapeutic potential of dietary antioxidants in polycystic ovary syndrome: a narrative review

Year: 2026

Type: review

Abstract: It is becoming more well acknowledged that oxidative stress is a crucial component that connects the hormonal, metabolic, and reproductive aspects of polycystic ovarian syndrome (PCOS). A more holistic and natural approach to managing the illness might be possible through lowering this disparity. This review outlines new findings about the effects of dietary antioxidants on critical processes related to PCOS, such as insulin signaling, inflammation, and mitochondrial activity. Antioxidants that have demonstrated encouraging effects in reducing oxidative stress, insulin resistance, and ovulatory health include N-acetylcysteine, coenzyme Q10, α-lipoic acid, and vitamins C and E. However, it's challenging to draw definitive findings due to limited intervention periods and variances in the study's methodology. More thorough, deeper, and more extensive standardized trials should be the main emphasis of future studies. Taken together, the results indicate that dietary antioxidants have significant medicinal value to help women with PCOS regain redox equilibrium and enhance their overall metabolic and reproductive health.

Source: Journal of Ovarian Research

DOI: 10.1186/s13048-026-02075-0

Authors: Nevin Adel Amer, Shatha Basheer Aldababseh, Doha Abdel Hady Abdel Gawad, Mostafa M. Abdelsadek, Rania Abdel Khalik Gouda, Abdela Befa Kinki