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Maternal exercise during lactation remodels obesity-associated mammary metabolism and milk fatty acids, enhancing offspring lipid oxidation

Year: 2026

Type: article

Abstract: Maternal obesity alters milk fatty acid composition, with consequences for postnatal metabolism. Maternal exercise during lactation in obese dams remodeled the mammary epithelial cell proteome, increasing medium-chain fatty acids in milk and enhancing offspring lipid oxidation.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00399.2025

Authors: Gertrude Kyere-Davies, Kaitlyn B. Hill, Gregory P. Mullen, Rohan R. Varshney, Snehasis Das, Alexandrea Martinez, Jacob W. Farriester, Michael Kinter, Cassie M. Mitchell, Kevin R. Short, Elvira M. Isganaitis, David A. Fields, Michael C. Rudolph

Institutions: University of Oklahoma, Oklahoma Medical Research Foundation, Harvard University

Language: English

Topic: Infant Nutrition and Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Oklahoma Center for Adult Stem Cell Research, Presbyterian Health Foundation, OU College of Medicine Alumni Association, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Diabetes, Endocrinology, and Metabolic Diseases

Awards: Maternal Obesity, Milk Composition, and Infant Growth, G8725299399, NR2F2 Pioneers Neonatal Beige Adipogenesis to Protect Against Later-life Obesity, Maternal exercise during lactation to ignite infant metabolism

OpenAlex ID: W7140120100

FWCI: 8.406

Cites: 84

Cited by: 2

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