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Genome sequence of protease-free Bacillus subtilis KO7-S strain created for protein production

Year: 2026

Type: article

Abstract: ABSTRACT Bacillus strains efficiently secrete heterologous recombinant proteins as well as multiple proteases, with the latter destroying the former. Strains deleted of multiple secreted proteases are, therefore, preferred as protein expression hosts. We report the genome sequence of one such easily available strain, Bacillus subtilis KO7-S.

Source: Microbiology Resource Announcements

DOI: 10.1128/mra.00016-26

Authors: Ankur Bothra, Ryan M. Routsong, Daniel R. Zeigler, Skyler Kuhn, Stephen H. Leppla

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, The Ohio State University

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: U.S. Department of Health and Human Services, National Institutes of Health, NHLBI Division of Intramural Research

OpenAlex ID: W7140120665

FWCI:

Cites: 16

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