Work

Funginocarterphenyls A–C: thiazole-containing p -terphenyls from Paulkirkia sp. KT4190

Year: 2026

Type: article

Abstract: Funginocarterphenyls A-C (1-3), which are thiazole-containing p-terphenyls, were identified from the fungus Paulkirkia sp. KT4190. Although structurally related p-terphenyls, such as nocarterphenyls (Wang et al. 2019) and echoside D (Deng et al. 2014), have been reported from actinomycete strains, these compounds represent the first examples isolated from filamentous fungi. The substitution pattern of the central hexasubstituted benzene ring was established via detailed hetero multiple-bond correlation spectral analyses. This was further verified by density-functional-theory-based chemical-shift calculations. Time-course analysis of compound production suggested their biosynthetic sequence.

Source: Bioscience Biotechnology and Biochemistry

DOI: 10.1093/bbb/zbag042

Authors: Rui Kanehira, Hayato Maeda, Kazuaki Tanaka, Masaru Hashimoto

Institution: Hirosaki University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,272

Funder: Hirosaki University