Work

Therapeutic potential of vagus nerve stimulation in neurodegenerative diseases: research progress and mechanisms

Year: 2026

Type: article

Abstract: Neurodegenerative diseases are a group of chronic, progressive neurological disorders caused by the degeneration and functional loss of neurons and glial cells, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD). Although numerous treatments are available for these diseases, therapeutic outcomes remain unsatisfactory because of their poorly understood pathogeneses of these diseases. Vagus nerve stimulation (VNS), a noninvasive or minimally invasive neuromodulation technique, has shown significant potential in mitigating neurodegenerative conditions. This review explores the mechanisms of action and clinical applications of VNS in neurodegenerative diseases, providing novel insights for the development of novel treatments.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2026.1811107

Authors: Qian Hu, Jiasheng Wang, Ruiyang Cao, Wenkai Liu, Lifeng Wang

Institutions: Gannan Medical University, First Affiliated Hospital of Gannan Medical University

Language: English

Topic: Vagus Nerve Stimulation Research

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801