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Anticoagulation in Atrial Fibrillation and Chronic Kidney Disease: A Critical Review and Future Perspectives in Peritoneal Dialysis

Year: 2026

Type: article

Abstract: Atrial fibrillation (AF) and chronic kidney disease (CKD) are two closely related pathophysiologically interconnected conditions, sharing common risk factors and resulting in poor clinical outcomes when coexisting. In patients with end-stage renal disease (ESRD) on renal replacement therapy, AF significantly complicates clinical management, as these patients have a doubled risk of death, stroke, and bleeding. Choosing the optimal anticoagulant strategy remains a major challenge, with direct oral anticoagulants (DOACs) emerging as a potentially superior alternative to vitamin K antagonists (VKAs), especially due to their renoprotective profile. However, data in patients on peritoneal dialysis (PD) remain sparse, constituting a significant gap in the scientific literature. This review examines the current state of evidence on anticoagulation in patients with AF and advanced CKD, with a particular focus on new therapeutic perspectives in the PD population.

Source: World Journal of Nephrology and Urology

DOI: 10.14740/wjnu1037

Authors: Aldo Franculli, Luca Di Lullo, Pasquale Saporito, Eleonora Bernabei, Laura Pedata, Vincenzo Barbera, Lorenzo D’Elia, Antonio Bellasi, Paola Peverini, Andrea Dello Strologo

Institution: Ospedale regionale di Lugano

Language: English

Topic: Atrial Fibrillation Management and Outcomes

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7140129784

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