Incidence and Risk Factors of Symptomatic Osteonecrosis in Children With Acute Lymphoblastic Leukemia—A Population‐Based Analysis of the Austrian ALL‐BFM Study Group
Year: 2026
Type: article
Abstract: Background: Osteonecrosis is a clinically relevant therapy-associated complication in pediatric acute lymphoblastic leukemia (ALL). Methods: In a nationwide Austrian cohort of 1127 patients with newly diagnosed ALL treated on AIEOP-BFM-ALL 2000 and 2009 protocols, 73 patients developed symptomatic osteonecrosis. Results: The corresponding 5-year cumulative incidence was 7% ± 1%, while competing events such as relapse, death, and secondary malignancies were at 13% ± 1%. Median time to osteonecrosis was 1.64 years. Age at diagnosis was the dominant risk factor: the 5-year incidence was 22% ± 3% in adolescent patients 10-18 versus 2% ± 0% in those 1-9 years-old. Conclusions: : The authors have confirmed clinical trial registration is not needed for this submission.
Source: eJHaem
DOI: 10.1002/jha2.70263
Authors: Katharina Arnold, Leila Ronceray, Martin Benesch, Roman Crazzolara, Michael Dworzak, Gernot Engstler, Anna Füreder, Neil Jones, Reinhold Kerbl, Paulina Kurzmann, Bernhard Meister, Ulrike Pötschger, Fiona Poyer, Hannah von Mersi, Christian Urban, Barbara Winkler, Andishe Attarbaschi, the Austrian Berlin‐Frankfurt‐Münster (BFM) Study Group
Institutions: St Anna Children's Hospital, Medical University of Vienna, St. Anna Children's Cancer Research Institute, Medical University of Graz, Innsbruck Medical University, Universität Innsbruck, University of Salzburg, Universitätskliniken Salzburg, LKH Hochsteiermark, Johannes Kepler University of Linz, Kepler Universitätsklinikum
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,860
OpenAlex ID: W7140137384