Year: 2026
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide A calcium-catalyzed approach to accessing α-functionalized amines via deacetylation has been developed. Using Ca(NTf 2 ) 2 / n BuNPF 6 as a mild Lewis acid system, a range of α-acetoxy substrates undergo smooth deacetylation and functionalization. The reaction displays excellent substrate tolerance and accommodates diverse nucleophiles, including sulfur, indole, amide, and cyanide derivatives. Furthermore, telescoped deprotection–reprotection protocols enable facile access to a variety of N -protected amines in high yields, providing a simple and practical route to valuable α-functionalized amine scaffolds.
Source: The Journal of Organic Chemistry
Authors: Michael P. Cameron, Mark G. McLaughlin
Institution: Queen's University Belfast
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funder: Queen's University Belfast
OpenAlex ID: W7140137445