Work

Acute metabolic effects of cannabinoid receptor modulators during sequential hyperglycemic, euglycemic-hyperinsulinemic clamps in healthy individuals

Year: 2026

Type: article

Abstract: Under controlled environment of the clamps in healthy, non-obese men, cannabinoid receptor agonist enhanced whereas cannabinoid receptor 1 antagonist diminished insulin sensitivity in a dose-dependent manner. During the clamps, elevated plasma insulin levels had a suppressive effect on circulating non-esterified fatty acids (NEFAs), anandamides (AEAs), and several N-acylethanolamines. Insulin, however, had no impact on circulating 2-arachidonoylglycerol (2-AG) levels. Neither the cannabinoid receptor agonist nor the cannabinoid receptor-1 antagonist had an effect on insulin secretion.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00391.2025