Year: 2026
Type: article
Abstract: In this issue, Yan et al. show that mitochondrial targeting signals (presequences) vary widely in import strength. Using the quantitative MitoLuc and PotLuc assays, they dissect multiple parameters of protein import and reveal how presequence features influence mitochondrial targeting efficiency and stress sensitivity.
Source: The Journal of Cell Biology
Authors: Carlotta Peselj, F.-Nora Vögtle
Institutions: Heidelberg University, DKFZ-ZMBH Alliance, University of Freiburg
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funder: Deutsche Forschungsgemeinschaft
Awards: G1014860659, G1514386576, G1799309044, In vivo Identifizierung und Charakterisierung der cytosolischen Transportwege mitochondrialer Vorstufenproteine, G259924242, G4695142958, EXC 2189: CIBSS Centre for Integrative Biological Signalling Studies, SFB 1381: Dynamische Organisation zellulärer Proteinmaschinerien: Von der Biogenese und modularen Assemblierung zur Funktion
OpenAlex ID: W7140177290