The interaction between glucose levels and body mass index on the regulation of the circulating sphingolipidome in humans
Year: 2026
Type: article
Study design: Observational Study
Abstract: Sphingolipid glycosylation is an enzymatic process that does not follow the pattern of nonenzymatic hemoglobin glycosylation. Unexpectedly, hexosyl- and lactosylceramides decreased in impaired fasting glucose and diabetes, with and without obesity. On the other hand, dihydroceramides increased in overweight/obesity with prediabetes/diabetes. The circulating sphingolipidome is differentially regulated in humans according to sex, glucose, and BMI.
Authors: Camillo Morano, Lucia Centofanti, Michele Dei Cas, Riccardo Zanzi, Giuseppe De Pinto, Monica Bignotto, Paola Zermiani, Elena Bianco, Federica Samartin, Sara Penati, Ilaria Pes, Ilaria Goggi, Pamela Senesi, Graziano Serrao, Loredana Bucciarelli, Francesca Bravi, Antonio Russo, Marco Trinchera, Pier Maria Battezzati, Monica Ferraroni, Franco Folli, Rita Paroni
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7140182286