Work

Divergent Access to Fluorinated Pharmacons From Ethyl Trifluoropyruvate

Year: 2026

Type: article

Abstract: Fluoro(oxo) functional groups, such as trifluoromethyl ketones, trifluoroethanols, and difluoromethyl ketones, have emerged as desirable motifs in medicinal chemistry. Traditionally, the installation of these functional groups is accomplished through the use of either designer reagents or nucleophilic trifluoromethylation. In contrast, commercially available fluorinated building blocks, such as ethyl trifluoropyruvate, can be used in a divergent manner to access a wide variety of fluoro(oxo) functional groups. Herein, we demonstrate facile activation of trifluoromethyl(hydroxy) esters for the divergent synthesis of fluorinated pharmacons.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70384

Authors: Rifat N. Nabi, Ryan C. Kashatus, Kaden M. Joseph, Salina Zhang, Daniel K. Kim

Institution: Temple University

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

Funder: National Institutes of Health