Research Progress on Spinal Cord Repair Based on Regulation of the Neuroregenerative Microenvironment
Year: 2026
Type: article
Abstract: Spinal cord injury is a disease with no complete cure. It typically results in loss of motor and sensory functions below the level of the lesion, leading to significant physical and psychological disorders. After spinal cord injury, the microenvironmental balance at the site of injury is disrupted, creating complex conditions that are not conducive to nerve regeneration and recovery of spinal cord function, such as hemorrhage and ischemia, glial scar formation, and nerve demyelination. As our knowledge of the spinal cord microenvironment has expanded, researchers have determined that therapeutic strategies that modulate the microenvironment represent a significant and efficacious avenue of investigation. This review summarizes the characteristics of microenvironmental changes at various stages after spinal cord injury. Additionally, it discusses novel strategies developed recently based on regulating the microenvironment after spinal cord injury to promote recovery. The investigation of a long-acting, targeted, and multitemporal combination therapy strategy to repair spinal cord injuries shows promise in terms of its developmental potential. A schematic overview of changes of microenvironment components after SCI and strategies for reconstructing microenvironment. NISCI Non-traumatic spinal cord injury, SCI Spinal cord injuryTSCI Traumatic spinal cord injury. Created with biorender.com
Authors: Zixiang Deng, Huijie Zhang, Xiaoyu Li, Yongbin Feng, Yang Liu, Hanfei Shang, Ming Li, Xiaoyi Zhou, Xianzhao Wei
Institutions: Second Military Medical University, Changhai Hospital
Language: English
Topic: Spinal Cord Injury Research
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,590
Funder: Changhai Hospital of Shanghai
OpenAlex ID: W7140185555