Patient-specific lung simulation incorporating regional elastance and recruitment to guide mechanical ventilation in acute respiratory distress syndrome
Year: 2026
Type: article
Abstract: This study presents a computational model for simulating ventilatory response in mechanically ventilated patients with acute respiratory distress syndrome and introduces a novel method to estimate patient-specific lung mechanical properties from a dual-volume computed tomography (CT) protocol. The key purpose of the in silico model proposed in this paper is to provide clinicians with a complementary modality that supports decision-making surrounding mechanical ventilation.
Source: Journal of Applied Physiology
Institutions: Eindhoven University of Technology, Inserm, Université Grenoble Alpes, Lyon 1 Université, Centre National de la Recherche Scientifique, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé, Institut National des Sciences Appliquées de Lyon, Catharina Ziekenhuis, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Centre Hospitalier Universitaire de Grenoble
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7140196601