Work

Export or explode: Export defects cause micronucleus membrane rupture

Year: 2026

Type: article

Abstract: Micronucleus membrane rupture drives genome instability; however, the mechanisms governing this phenomenon remain unclear. Zych and colleagues reveal that impaired protein export, caused by reduced levels of the transport protein RCC1, drives micronucleus expansion, leading to nuclear envelope rupture.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202603041

Authors: Hiba Baaziz, Daniela Cimini

Institution: Virginia Tech

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institutes of Health