Work

Pyrazole-functionalized Zr-MOF and membrane as efficient and recyclable catalyst for multi-component Hantzsch condensation reaction

Year: 2026

Type: article

Abstract: • Cost-effective, robust, pyrazole-functionalized DUT-67-PZDC MOF have been demonstrated for the Hantzsch reaction • Excellent yield of substrates was demonstrated with a wide substrate scope. • Catalyst displayed high Turnover numbers and Turnover frequency • Easy processability of the catalyst to the membrane for facile recovery and recyclability was confirmed • The catalyst can perform multi-fold Hantzsch reaction Dihydropyridines, owing to their diverse biological activities, are an important class of heterocyclic scaffolds in pharmaceutical chemistry. Commonly used methodology for the synthesis of DHPs is the Hantzsch Condensation reaction in the presence of a catalyst. Herein, we present a pyrazole-functionalized robust Zr-Metal Organic Framework, DUT-67-PZDC, and its membrane for tandem Hantzsch Condensation reaction. The presence of pyrazole moieties introduces Lewis basic sites, while the Zr cluster serves as Lewis acidic sites, facilitating the multicomponent condensation of aldehydes, β-ketoesters, and ammonium acetate under mild conditions, affording the corresponding 1,4-dihydropyridine derivatives with excellent yields (≥90%), Turnover number (∼55-102) and turnover frequency (8.7-17 h -1 ). Notably, MOF-derived self-standing membrane exhibits similar activity while improving the catalyst recovery. Both powder and membrane forms of DUT-67-PZDC demonstrate high stability and retain catalytic performance over multiple reaction cycles, ensuring their recyclability. This catalyst not only provides a broad substrate scope but also facilitates a multifold Hantzsch Condensation reaction.

Source: Chemical Engineering Journal Advances

DOI: 10.1016/j.ceja.2026.101156

Authors: Swetha Jaisankar, Shyamapada Nandi

Institution: Vellore Institute of Technology University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: $2,050