Work

Longitudinal changes in coagulation-fibrinolysis in patients with traumatic brain injury within seven days after injury

Year: 2026

Type: article

Abstract: Traumatic brain injury (TBI)-induced coagulopathy is associated with poor outcomes of patients, but its progression remains poorly understood. We longitudinally collected peripheral venous blood samples from patients with TBI 24 h, 3 days, and 7 days after injury, and analyzed the samples for conventional blood and conventional coagulation tests, thromboelastography, coagulation factor activity, platelet activity, and levels of extracellular vesicles through laboratory tests. By detecting longitudinal changes in the coagulation-fibrinolysis, we found that TBI patients were in a state of hyperfibrinolysis within 24 h after injury, but transitioned to a hypercoagulable state on the 7 th day after injury. And, the concentrations of extracellular vesicles continued to increase from 24 h to 7 days after injury. We identified the early changes in TBI-induced coagulopathy, namely that TBI patients undergo a transition from a hyperfibrinolytic state to a hypercoagulable state within 24 h to 7 days post-injury.

Source: iScience

DOI: 10.1016/j.isci.2026.115443

Authors: Xinlong Dong, Nanyu Yao, Limin Zhang, Guanghui Zheng, Yutong Zhao, Weiming Liu

Institutions: Capital Medical University, Beijing Tian Tan Hospital

Language: English

Topic: Trauma, Hemostasis, Coagulopathy, Resuscitation

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240