Work

Estimating the Sensitivity of Nontreponemal and Treponemal Antibody Tests in Primary Syphilis

Year: 2026

Type: article

Study design: Observational Study

Abstract: Among patients with primary syphilis, sensitivity of the toluidine red unheated serum test was 55% (6/11) compared with darkfield microscopy and 60% (9/15) compared with Treponema pallidum polymerase chain reaction. Sensitivity of rapid plasma reagin was 78% (38/49) and 93% (43/46), respectively. Treponema pallidum particle agglutination had a sensitivity of 95% (41/43) compared with darkfield microscopy and 96% (43/45) compared with polymerase chain reaction.

Source: Sexually Transmitted Diseases

DOI: 10.1097/olq.0000000000002297

Authors: Stephanie F. Sweitzer, Jane S. Chen, Mitch M. Matoga, Ligang Yang, Eduardo Lopez-Medina, Jonny A. Garcia-Luna, Irving F. Hoffman, Bin Yang, Juan C. Salazar, Justin D. Radolf, Jonathan B. Parr, Arlene C. Seña

Institutions: University of North Carolina at Chapel Hill, Southern Medical University, Centro Internacional de Entrenamiento e Investigaciones Medicas, Universidad del Valle, Icesi University, Connecticut Children's Medical Center, UConn Health

Language: English

Topic: Syphilis Diagnosis and Treatment

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Bill and Melinda Gates Foundation, Eli Lilly and Company, Pfizer, Gilead Sciences, American Sexually Transmitted Diseases Association, Connecticut Children's Medical Center, Universidad de Antioquia, Galderma, National Institutes of Health, Abbott Diagnostics, National Institute of Allergy and Infectious Diseases

Awards: G24891921, A Global Syphilis Vaccine Targeting Outer Membrane Proteins of Treponema pallidum., University of North Carolina at Chapel Hill - to characterize T. pallidum strain diversity in Africa, Asia, and Latin America, Training in Sexually Transmitted Infections and HIV

OpenAlex ID: W7140215546

FWCI:

Cites: 20

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