Work

Net Oxidative Photocatalytic Strategy toward the o -Trifluoroacetylation of N -Heteroarenes

Year: 2026

Type: article

Abstract: The direct introduction of fluorinated functional groups into small molecules remains one of the most powerful chemical transformations toward synthesizing biologically active compounds. Heteroaromatics are particularly significant scaffolds, and fluorofunctionalization reactions are still in demand. Herein, we report a protocol to synthesize heteroaromatic trifluoromethyl ketones (TFMKs), installed through photomediated Minisci coupling, followed by subsequent deketalization. We have demonstrated the key Minisci reaction in more than 10 unique heterocyclic classes, notably including pyridines, pyrazines, pyridazines, pyrimidines, quinolines, and polycyclic systems, alongside select deketalizations of high-value aromatics.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6c00477

Authors: Kyra L. Samony, Jabez Z. Thullaprambil, Rifat N. Nabi, Kyle E. Brunner, Daniel K. Kim

Institution: Temple University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500