Work

Error Compensation without a Time Penalty: Robust Spin-Lock-Induced Crossing in Solution NMR

Year: 2026

Type: article

Abstract: A modification of the widely used spin-lock-induced crossing (SLIC) procedure is proposed for the solution nuclear magnetic resonance (NMR) of strongly coupled nuclear spin systems, including singlet NMR and parahydrogen-enhanced hyperpolarized NMR experiments. The compensated-SLIC (cSLIC) scheme uses a repetitive sequence where the repeated element employs two different radio-frequency field amplitudes. Effective compensation for deviations in the radio-frequency field amplitude is achieved without increasing the overall duration of the SLIC sequence. The advantageous properties of cSLIC are demonstrated by numerical simulations and representative experiments.

Source: The Journal of Physical Chemistry Letters

DOI: 10.1021/acs.jpclett.6c00524

Authors: Mohamed Sabba, Christian Bengs, Urvashi D. Heramun, Malcolm H. Levitt

Institution: University of Southampton

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Engineering and Physical Sciences Research Council, HORIZON EUROPE European Research Council