Work

Targeting JAK/STAT signalling with cold atmospheric plasma: a potential therapy for systemic lupus erythematosus

Year: 2026

Type: article

Abstract: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous multi-organ manifestations and poorly understood pathogenesis. The variable therapeutic outcomes and potential for cross-indication treatments underscore the need to identify pivotal disease-driving signalling pathways for developing innovative and safer regimens. By categorizing the pathogenesis of SLE into three interconnected stages involving over-activated immune response, skewed cytokine homeostasis and impaired debris clearance, and by analysing public clinical data, this review posits that the Janus kinase-signal transducer and activator of transcription axis is a central driver of SLE pathogenesis. Accordingly, it explores the potential of cold atmospheric plasma to modulate this pathway for therapeutic benefit that requires further experimental and clinical validations.

Source: Expert Reviews in Molecular Medicine

DOI: 10.1017/erm.2026.10042

Authors: Xiaofeng Dai, Yuting Fan, Zizheng Huang

Institutions: First Affiliated Hospital of Xi'an Jiaotong University, Affiliated Hospital of Guizhou Medical University

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,550