Work

Cobalt-Catalyzed [2+2+2] Cycloadditions of Alkynyl Yndiamides with Nitriles

Year: 2026

Type: article

Abstract: Herein is described a convenient cobalt-catalyzed [2+2+2] cycloaddition of alkynyl yndiamides with nitriles. This regioselective reaction provides access to 39 novel valuable 2,3-dihydro-1 H -pyrrolo[2,3- c ]pyridin-7-amine or (1,2,3,4-tetrahydro-1,7-naphthyridin-8-yl)-9 H -carbazole derivatives. These highly substituted pyridines are important building blocks in medicinal chemistry. The process is eco-friendly since the cycloaddition is conducted in a green solvent with a non-noble transition metal catalyst.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6c00823

Authors: Jun Fang, William Parisot, Phannarath Phansavath, Virginie Ratovelomanana-Vidal

Institutions: Centre National de la Recherche Scientifique, Chimie ParisTech - PSL, Université Paris Sciences et Lettres, Institute of Chemistry for Life and Health Sciences

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: China Scholarship Council, Centre National de la Recherche Scientifique

Award: G2711911680