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The γ -Valerolactone (GVL) as Innoxious Reaction Media for the Synthesis of 2-Aryl-2 H -Indazoles via C-N and N-N Bond Formation under Cu(I)-Catalyzed Ligand and Base Free Conditions

Year: 2024

Type: article

Abstract: An efficient method for N-arylation and N-N bond formation has been developed using an innoxious reaction medium, c-valerolactone (GVL), as both a solvent and a ligand.The strategy involves utilizing CuI as a catalyst under conditions free of external ligands and bases.Various aldehyde and amine derivatives with different functional groups were investigated, resulting in the production of 2-aryl-2H-indazole compounds with yields ranging from 75% to 93%.This study highlights the effectiveness of GVL, a solvent derived from biomass, as a reaction medium and ligand in a multicomponent reaction.

Source: Repository KITopen (Karlsruhe Institute of Technology)

DOI: 10.5445/ir/1000163861

Authors: Singh, Laimujam Sidartha, Kant, Kamal, Banerjee, Sourav, Sengupta, Ragini, AlObaid, Abeer A., Pal, Maynak, Dutta, Saikat, Aljaar, Nayyef, Malakar, Chandi C.

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: King Saud University, Ministry of Education, India, Science and Engineering Research Board

Awards: G254104781, G2865102743, G8132664439

OpenAlex ID: W7140224671

FWCI:

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