Work

Direct Oral Anticoagulants and Incidence of Dementia in Patients With Nonvalvular Atrial Fibrillation

Year: 2026

Type: article

Abstract: In patients with atrial fibrillation (AF), oral anticoagulation is essential for stroke prevention and may also prevent dementia. Although the class of direct oral anticoagulants (DOACs) have been associated with a decreased risk of dementia compared to warfarin, it is unknown if differences exist among the individual DOACs. Our primary objective was to compare the dementia risk among AF patients initiating different DOACs, with head-to-head comparisons between apixaban, edoxaban, and rivaroxaban.

Source: Neurology Open Access

DOI: 10.1212/wn9.0000000000000077

Authors: Julien Quang Le Van, Sarah Beradid, Erica E.M Moodie, James M. Brophy, Madeleine Durand, Jason Robert Guertin, Jean-Francois Boivin, Christel Renoux

Institutions: Montreal Heart Institute, Jewish General Hospital, Lady Davis Institute for Medical Research, McGill University, Université de Montréal, Centre Hospitalier de l’Université de Montréal, Université Laval, Centre de recherche du CHU de Québec-Université Laval

Language: English

Topic: Atrial Fibrillation Management and Outcomes

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7140227390

FWCI:

Cites: 32

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