Work

Clinical characteristics, treatment options, and prognosis of subcutaneous panniculitis-like T-cell lymphoma from the SEER database

Year: 2026

Type: article

Abstract: Introduction Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare type of cutaneous lymphoma lacking standardized treatments. Consequently, patient outcomes vary significantly.Methods This study explored the clinical characteristics and prognostic factors of 205 SPTCL patients from 2000 to 2021 in the Surveillance, Epidemiology, and End Results (SEER) database.Results Overall survival (OS) at 1, 3, and 5 years were 78.3%, 75.7%, and 66.4%, respectively. Patients diagnosed after 2008 (possibly excluding the γ–δ subtype) (HR = 0.197, 95% CI = 0.106–0.364, p = 0.000) and Asian or Pacific Islanders (HR = 0.210, 95% CI = 0.049–0.902, p = 0.036) were independent predictors of favorable survival, whereas age 50–60 years (HR = 3.213, 95% CI = 1.357–7.607, p = 0.008) and age > 60 years (HR = 5.039, 95% CI = 2.327–10.911, p = 0.000) were independently associated with poor survival. Patients who received radiotherapy alone exhibited a significantly lower hazard risk compared to those receiving no chemotherapy or radiation (HR = 0.216, 95% CI = 0.048–0.983, p = 0.048). No statistically significant differences in prognosis were observed between patients who received no chemotherapy or radiation and those who received either chemotherapy alone (HR = 1.276, 95% CI = 0.644–2.529, p = 0.485) or radiochemotherapy (HR = 1.283, 95% CI = 0.463–3.558, p = 0.632). These associations persisted after IPTW adjustment, with age, race, year of diagnosis, and treatment remaining independent predictors of OS in SPTCL.Conclusions The Ann Arbor staging was not suitable for SPTCL. Radiotherapy represents an appropriate therapeutic option for patients with single or localized skin lesions. No statistically significant differences in prognosis were observed between patients who received no chemotherapy or radiation and those who received either chemotherapy alone or radiochemotherapy. This finding suggests that immunomodulatory agents may be preferable to cytotoxic therapy as initial treatment for SPTCL, an inflammatory lymphoma.

Source: Hematology

DOI: 10.1080/16078454.2026.2648344

Authors: Lijuan Zhang, Zehui Chen, Longhua Lu, Bing Xiang

Institutions: Sichuan University, West China Hospital of Sichuan University, Putian University

Language: English

Topic: Cutaneous lymphoproliferative disorders research

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,557