Work

WCN26-8685 Serum levels of CMPF, a protein-bound uremic toxin, across different kidney replacement modalities

Year: 2026

Type: article

Abstract: The protein-bound solute 2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid (CMPF), a metabolite derived from furan fatty acids, has been classified as a uremic toxin. Elevated CMPF levels have been reported in patients with chronic kidney disease (CKD), and emerging evidence suggests its potential impact on erythrocyte biology (Van Spitzenbergen, Nephrol Dial Transplant. 2025 Jun 30;40(7):1342-1349. https://doi.org/10.1093/ndt/gfae275). This study aimed to quantify total serum CMPF levels in individuals with CKD undergoing different renal replacement therapy modalities.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2026.104542

Authors: Beatriz Akemi Kondo Van Spitzenbergen, Rayane De Cássia Cagni Vicentin, Nadja Grobe, Andrea N. Moreno-Amaral, Peter Kotanko

Institutions: Pontifícia Universidade Católica do Paraná, Renal Research Institute

Language: English

Topic: Dialysis and Renal Disease Management

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800