Work

Wcn26-4327 Role of Tfam in Managing Diabetic Kidney Disease

Year: 2026

Type: article

Abstract: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease in the U.S. Despite the rapid development of several therapies, the ability to target intrinsic kidney metabolic pathways remains somehow limited. Recently impaired mitophagy and innate immunity have been recognized as drivers of tubulointerstitial injury DKD. Our prior work discovered that glomeruli in experimental DKD exhibit sterile inflammation driven by stimulator of interferon genes (STING) activation, which results in podocyte apoptosis and autophagic death.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2026.104620