The role of kidney transplantation in the management of erectile dysfunction: a review of hormonal changes and psychosocial impacts in male patients
Year: 2025
Type: article
Abstract: INTRODUCTION: Kidney transplantation is a life-saving intervention for patients with end-stage renal disease (ESRD), significantly improving longevity and quality of life compared to dialysis. However, despite these benefits, a considerable proportion of male recipients (20%-50%) continue to experience erectile dysfunction (ED), highlighting an ongoing concern in post-transplant health management. OBJECTIVES: The aim of this review is to examine the role of kidney transplantation in addressing erectile dysfunction, with a particular focus on the interplay between hormonal changes, specifically testosterone and thyroid hormones and psychosocial factors such as anxiety, depression, and overall quality of life, by analyzing the multifactorial etiology of ED, including neurovascular, hormonal, and psychological dimensions. METHODS: A comprehensive analysis of existing literature was conducted, focusing on studies that examine ED prevalence, underlying mechanisms, and treatment approaches in kidney transplant recipients. Articles were selected based on their relevance to hormonal, psychological, and metabolic factors contributing to post-transplant sexual dysfunction. RESULTS: Findings indicate that persistent hormonal imbalances, including altered testosterone and thyroid hormone levels, significantly contribute to ED post-transplant. Additionally, psychosocial factors such as anxiety, depression, and reduced quality of life exacerbate the condition. Current therapeutic approaches emphasize a multidisciplinary framework that integrates hormonal regulation, psychological support, and metabolic management to address ED effectively. CONCLUSION: Addressing ED in kidney transplant recipients requires a comprehensive approach that considers both physiological and psychological factors. Future research may focus on refining treatment protocols by incorporating hormonal therapies, mental health interventions, and lifestyle modifications to optimize sexual health outcomes and overall well-being in this vulnerable population.
Source: Sexual Medicine Reviews
Authors: Muhammad Adil Malik, Quan Zhuang, Imtiaz Ahmad
Institutions: Central South University, Third Xiangya Hospital
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7140464382