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Barriers to Isotretinoin Access and Treatment Continuity in an Underserved Pediatric Population: A Cross‐Sectional Study

Year: 2026

Type: article

Abstract: Isotretinoin is a highly effective treatment for severe acne, but its use is often complicated by scheduling, pharmacy, and iPLEDGE-related barriers that may contribute to greater administrative burden for patients facing pre-existing structural barriers to care. We conducted a cross-sectional survey study of 42 pediatric patients at an urban safety-net hospital who had completed at least 1 month of isotretinoin, assessing demographics, treatment experience, and barriers to use. Overall, 64.3% of patients reported appointment, pharmacy, or financial-related difficulties, contributing to treatment gaps in 33.3%; nevertheless, 97.6% felt their treatment was successful. Despite high perceived efficacy, isotretinoin use was impacted by administrative and iPLEDGE-related requirements, potentially magnifying existing access barriers.

Source: Pediatric Dermatology

DOI: 10.1111/pde.70184

Authors: Charles B. Lau, Laxmi Behara, Susruthi Rajanala, Margaret Lee, Lisa Y. Shen

Institutions: Boston University, The University of Texas Health Science Center at Houston, University of Miami

Language: English

Topic: Acne and Rosacea Treatments and Effects

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: green

OpenAlex ID: W7140466371

FWCI: 6.193

Cites: 8

Cited by: 1

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