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Are high residual chlorhexidine skin concentrations associated with improved clinical outcomes? Lessons from the CLEAR trial

Year: 2026

Type: article

Abstract: Residual chlorhexidine gluconate (CHG) skin concentrations are thought to improve disease prevention. In the Changing Lives by Eradicating Antibiotic Resistance (CLEAR) trial, posthospitalization decolonization of MRSA carriers reduced MRSA infection and all-cause infection, but higher residual CHG concentrations did not improve outcomes. CHG concentration may indicate bathing quality, but high residual concentrations may not be necessary for benefit.

Source: Infection Control and Hospital Epidemiology

DOI: 10.1017/ice.2026.10424

Authors: Roya Khoja, Tabitha D. Catuna, Gabrielle M. Gussin, Kevin Nguyen, Raveena D. Singh, Mary K. Hayden, Loren G. Miller, Susan S. Huang

Institutions: University of California, Irvine, Rush University Medical Center, University of California, Los Angeles, The Lundquist Institute, Harbor–UCLA Medical Center, University of California System

Language: English

Topic: Infection Control in Healthcare

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,550

Funders: National Institutes of Health, Agency for Healthcare Research and Quality, National Institute of Allergy and Infectious Diseases

Award: PROJECT CLEAR - CHANGING LIVES BY ERADICATING ANTIBIOTIC RESISTANCE

OpenAlex ID: W7140520668

FWCI:

Cites: 9

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