Work

Muscle atrophy after ACL reconstruction involves molecular mechanisms beyond unloading

Year: 2026

Type: article

Abstract: Disuse is often suggested as a major driver of quadriceps pathology following anterior cruciate ligament reconstruction (ACLR). This study identifies shared and unique gene signatures that occur early with ACLR and unilateral lower limb suspension (ULLS), highlighting ACLR-specific responses that likely contribute to prolonged quadriceps atrophy and weakness.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00088.2026

Authors: Alexander R. Keeble, Sara Gonzalez-Velez, Nicholas T. Thomas, Allison M. Owen, Austin V. Stone, Darren L. Johnson, Julián Candia, Luigi Ferrucci, Marco Narici, Esther E. Dupont-Versteegden, Brian Noehren, Martino V. Franchi, Christopher S. Fry

Institutions: University of Kentucky, National Institute on Aging, University of Padua

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Arthrex, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G1362167466, Myostatin Alters Muscle Composition as The Result of an ACL Injury

OpenAlex ID: W7140534046

FWCI: 3.656

Cites: 48

Cited by: 2

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